There is a brief introductory summary of purinergic signaling involving ATP storage, release,
and ectoenzymatic breakdown, and the current classification of receptor subtypes for
purines and pyrimidines. The review then describes purinergic mechanosensory
transduction involved in visceral, cutaneous, and musculoskeletal nociception and on the
roles played by receptor subtypes in neuropathic and inflammatory pain. Multiple
purinoceptor subtypes are involved in pain pathways both as an initiator and modulator …