The relationship of desoxyribonuclease inhibitor levels in human sera to the occurrence of antinuclear antibodies
PG Frost, PJ Lachmann - Clinical and Experimental …, 1968 - pmc.ncbi.nlm.nih.gov
PG Frost, PJ Lachmann
Clinical and Experimental Immunology, 1968•pmc.ncbi.nlm.nih.govA group of sera from hospital patients and normal subjects has been tested for the presence
of antinuclear antibodies, and the amount of labile inhibitor to desoxyribonuclease 1 present
in each of the sera estimated. It has been found that the presence of antinuclear antibodies
is associated with a high level of inhibitor to a statistically significant degree. It has also been
found that this inhibitor is formed during the clotting of whole blood and that it is derived from
platelets. A possible relationship between the inhibitor, its formation during the clotting of …
of antinuclear antibodies, and the amount of labile inhibitor to desoxyribonuclease 1 present
in each of the sera estimated. It has been found that the presence of antinuclear antibodies
is associated with a high level of inhibitor to a statistically significant degree. It has also been
found that this inhibitor is formed during the clotting of whole blood and that it is derived from
platelets. A possible relationship between the inhibitor, its formation during the clotting of …
A group of sera from hospital patients and normal subjects has been tested for the presence of antinuclear antibodies, and the amount of labile inhibitor to desoxyribonuclease 1 present in each of the sera estimated. It has been found that the presence of antinuclear antibodies is associated with a high level of inhibitor to a statistically significant degree. It has also been found that this inhibitor is formed during the clotting of whole blood and that it is derived from platelets. A possible relationship between the inhibitor, its formation during the clotting of blood, and the characteristic presence of antinuclear antibodies in systemic lupus erythematosus is discussed.
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