ContextEpidemiological and experimental evidence suggests that high levels of vitamin D, a
potent immunomodulator, may decrease the risk of multiple sclerosis. There are no
prospective studies addressing this hypothesis. ObjectiveTo examine whether levels of 25-
hydroxyvitamin D are associated with risk of multiple sclerosis. Design, Setting, and
ParticipantsProspective, nested case-control study among more than 7 million US military
personnel who have serum samples stored in the Department of Defense Serum Repository …