The interactive effect of improvement of vitamin D status and VDR FokI variants on oxidative stress in type 2 diabetic subjects: a randomized controlled trial
European journal of clinical nutrition, 2015•nature.com
Results: After 12 weeks, serum 25 (OH) D increased significantly in FD (from 38.5±202.2 to
72.0±23.5, P< 0.001) as compared with PD (from 38.8±22.8 to 33.4±22.8, P= 0.28).
Comparisons between FD and PD revealed significant differences in changes of serum
MDA (− 0.54±0.82 μmol/l vs+ 0.17±1 μmol/l, P< 0.001), GSH (+ 8.4±40.1 ng/l vs− 13.1±29.4
ng/l, P= 0.002) and TAC (+ 0.14±0.43 mmol/l vs+ 0.02±0.45 mmol/l bovine serum albumin
equivalent, P= 0.03). Although there was no significant association between FokI genotypes …
72.0±23.5, P< 0.001) as compared with PD (from 38.8±22.8 to 33.4±22.8, P= 0.28).
Comparisons between FD and PD revealed significant differences in changes of serum
MDA (− 0.54±0.82 μmol/l vs+ 0.17±1 μmol/l, P< 0.001), GSH (+ 8.4±40.1 ng/l vs− 13.1±29.4
ng/l, P= 0.002) and TAC (+ 0.14±0.43 mmol/l vs+ 0.02±0.45 mmol/l bovine serum albumin
equivalent, P= 0.03). Although there was no significant association between FokI genotypes …
Results:
After 12 weeks, serum 25 (OH) D increased significantly in FD (from 38.5±202.2 to 72.0±23.5, P< 0.001) as compared with PD (from 38.8±22.8 to 33.4±22.8, P= 0.28). Comparisons between FD and PD revealed significant differences in changes of serum MDA (− 0.54±0.82 μmol/l vs+ 0.17±1 μmol/l, P< 0.001), GSH (+ 8.4±40.1 ng/l vs− 13.1±29.4 ng/l, P= 0.002) and TAC (+ 0.14±0.43 mmol/l vs+ 0.02±0.45 mmol/l bovine serum albumin equivalent, P= 0.03). Although there was no significant association between FokI genotypes and OS biomarkers, ff variant subgroup showed the weakest response to vitamin D.
Conclusions:
Improvement of vitamin D status via daily intake of FD ameliorates OS biomarkers in T2D subjects and the interactive effect of FokI genotypes cannot be ruled out.
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