Gut microbiota drive the development of neuroinflammatory response in cirrhosis in mice
DJ Kang, NS Betrapally, SA Ghosh, RB Sartor… - Hepatology, 2016 - journals.lww.com
The expression of biliary/progenitor markers by hepatocellular carcinoma (HCC) is often
associated with poor prognosis and stem cell‐like behaviors of tumor cells. Hepatocellular
adenomas (HCAs) also often express biliary/progenitor markers and frequently act as
precursor lesions for HCC. However, the cell of origin of HCA and HCC that expresses these
markers remains unclear. Therefore, to evaluate if mature hepatocytes give rise to HCA and
HCC tumors and to understand the molecular pathways involved in tumorigenesis, we …
associated with poor prognosis and stem cell‐like behaviors of tumor cells. Hepatocellular
adenomas (HCAs) also often express biliary/progenitor markers and frequently act as
precursor lesions for HCC. However, the cell of origin of HCA and HCC that expresses these
markers remains unclear. Therefore, to evaluate if mature hepatocytes give rise to HCA and
HCC tumors and to understand the molecular pathways involved in tumorigenesis, we …