[HTML][HTML] Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
Bile acid concentrations are controlled by a feedback regulatory pathway whereby activation
of the farnesoid X receptor (FXR) represses transcription of both the CYP7A1 gene,
encoding the rate-limiting enzyme in the classic bile acid synthesis pathway, and the
CYP8B1 gene, required for synthesis of cholic acid. The tissue-specific roles of FXR were
examined using liver-and intestine-specific FXR-null models. FXR deficiency in either liver
(Fxr ΔL) or intestine (Fxr ΔIE) increased bile acid pool size. Treatment with the FXR-selective …
of the farnesoid X receptor (FXR) represses transcription of both the CYP7A1 gene,
encoding the rate-limiting enzyme in the classic bile acid synthesis pathway, and the
CYP8B1 gene, required for synthesis of cholic acid. The tissue-specific roles of FXR were
examined using liver-and intestine-specific FXR-null models. FXR deficiency in either liver
(Fxr ΔL) or intestine (Fxr ΔIE) increased bile acid pool size. Treatment with the FXR-selective …