Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

G Kakiyama, WM Pandak, PM Gillevet, PB Hylemon… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: The 7α-dehydroxylation of primary bile acids (BAs),
chenodeoxycholic (CDCA) and cholic acid (CA) into the secondary BAs, lithocholic (LCA)
and deoxycholic acid (DCA), is a key function of the gut microbiota. We aimed at studying
the linkage between fecal BAs and gut microbiota in cirrhosis since this could help
understand cirrhosis progression. METHODS: Fecal microbiota were analyzed by culture-
independent multitagged-pyrosequencing, fecal BAs using HPLC and serum BAs using LC …