Upregulation of TNF-alpha production signaling pathways in monocytes from patients with advanced cirrhosis: possible role of Akt and IRAK-M
KA Tazi, JJ Quioc, V Saada, A Bezeaud, D Lebrec… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: In cirrhosis, tumor necrosis factor (TNF)-alpha overproduction is
involved in both the systemic complications and progression of liver injury. Since monocytes
from patients with advanced cirrhosis have an increase in lipopolysaccharide (LPS)-induced
TNF-alpha production, we hypothesized that an upregulation of TNF-alpha production
pathways and/or alteration of constitutive and inducible suppressor of TNF-alpha
hyperproduction (protein kinase B (Akt) and interleukin-1 receptor-associated kinase (IRAK) …
involved in both the systemic complications and progression of liver injury. Since monocytes
from patients with advanced cirrhosis have an increase in lipopolysaccharide (LPS)-induced
TNF-alpha production, we hypothesized that an upregulation of TNF-alpha production
pathways and/or alteration of constitutive and inducible suppressor of TNF-alpha
hyperproduction (protein kinase B (Akt) and interleukin-1 receptor-associated kinase (IRAK) …