[HTML][HTML] IL-15 induces Alloreactive CD28− memory CD8 T cell proliferation and CTLA4-Ig resistant memory CD8 T cell activation
O Traitanon, A Gorbachev, JJ Bechtel, KS Keslar… - American Journal of …, 2014 - Elsevier
The presence of CD28− memory CD8 T cells in the peripheral blood of renal transplant
patients is a risk factor for graft rejection and resistance to CTLA-4Ig induction therapy. In
vitro analyses have indicated poor alloantigen-induced CD28− memory CD8 T cell
proliferation, raising questions about mechanisms mediating their clonal expansion in
kidney grafts to mediate injury. Candidate proliferative cytokines were tested for synergy with
alloantigen in stimulating CD28− memory CD8 T cell proliferation. Addition of IL-15, but not …
patients is a risk factor for graft rejection and resistance to CTLA-4Ig induction therapy. In
vitro analyses have indicated poor alloantigen-induced CD28− memory CD8 T cell
proliferation, raising questions about mechanisms mediating their clonal expansion in
kidney grafts to mediate injury. Candidate proliferative cytokines were tested for synergy with
alloantigen in stimulating CD28− memory CD8 T cell proliferation. Addition of IL-15, but not …