Short Communication: Elevated Substance P Levels in HIV-Infected Women in Comparison to HIV-Negative Women

SD Douglas, A Cnaan, KG Lynch, T Benton… - AIDS research and …, 2008 - liebertpub.com
SD Douglas, A Cnaan, KG Lynch, T Benton, H Zhao, DR Gettes, DL Evans
AIDS research and human retroviruses, 2008liebertpub.com
Substance P and its receptor (neurokinin-1R) are potent modulators of
neuroimmunoregulation and HIV/AIDS infection. We previously demonstrated that HIV-
seropositive men had significantly higher substance P levels compared to uninfected
controls. We now demonstrate that substance P plasma levels are significantly higher in HIV-
infected women in comparison to uninfected control women.
Substance P and its receptor (neurokinin-1R) are potent modulators of neuroimmunoregulation and HIV/AIDS infection. We previously demonstrated that HIV-seropositive men had significantly higher substance P levels compared to uninfected controls. We now demonstrate that substance P plasma levels are significantly higher in HIV-infected women in comparison to uninfected control women.
Mary Ann Liebert