Substance P enhances HIV-1 replication in latently infected human immune cells
Y Li, SD Douglas, L Song, S Sun, WZ Ho - Journal of Neuroimmunology, 2001 - Elsevier
Substance P (SP) is a potent modulator of neuroimmunoregulation. SP receptors are
present on human monocytes and T lymphocytes, and SP alters the function of these
immune cells. We investigated the effects of SP on HIV-1 replication in latently infected
human immune cells. SP significantly enhanced HIV-1 replication in the latently infected
promonocytic cell line (U1) and T lymphocyte line (ACH-2) stimulated with tumor necrosis
factor (TNF-α). When added to these cells in combination with TNF-α, SP also enhanced HIV …
present on human monocytes and T lymphocytes, and SP alters the function of these
immune cells. We investigated the effects of SP on HIV-1 replication in latently infected
human immune cells. SP significantly enhanced HIV-1 replication in the latently infected
promonocytic cell line (U1) and T lymphocyte line (ACH-2) stimulated with tumor necrosis
factor (TNF-α). When added to these cells in combination with TNF-α, SP also enhanced HIV …