[HTML][HTML] Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance …
Diarrhea is one of the most common adverse side effects observed in∼ 7% of individuals
consuming Food and Drug Administration (FDA)-approved drugs. The mechanism of how
these drugs alter fluid secretion in the gut and induce diarrhea is not clearly understood.
Several drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4),
such as the anti-colon cancer drug irinotecan and an anti-retroviral used to treat HIV
infection, 3′-azido-3′-deoxythymidine (AZT). These drugs activate cystic fibrosis …
consuming Food and Drug Administration (FDA)-approved drugs. The mechanism of how
these drugs alter fluid secretion in the gut and induce diarrhea is not clearly understood.
Several drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4),
such as the anti-colon cancer drug irinotecan and an anti-retroviral used to treat HIV
infection, 3′-azido-3′-deoxythymidine (AZT). These drugs activate cystic fibrosis …