The mouse as a model for human biology: a resource guide for complex trait analysis
Nature Reviews Genetics, 2007•nature.com
The mouse has been a powerful force in elucidating the genetic basis of human physiology
and pathophysiology. From its beginnings as the model organism for cancer research and
transplantation biology to the present, when dissection of the genetic basis of complex
disease is at the forefront of genomics research, an enormous and remarkable mouse
resource infrastructure has accumulated. This review summarizes those resources and
provides practical guidelines for their use, particularly in the analysis of quantitative traits.
and pathophysiology. From its beginnings as the model organism for cancer research and
transplantation biology to the present, when dissection of the genetic basis of complex
disease is at the forefront of genomics research, an enormous and remarkable mouse
resource infrastructure has accumulated. This review summarizes those resources and
provides practical guidelines for their use, particularly in the analysis of quantitative traits.
Abstract
The mouse has been a powerful force in elucidating the genetic basis of human physiology and pathophysiology. From its beginnings as the model organism for cancer research and transplantation biology to the present, when dissection of the genetic basis of complex disease is at the forefront of genomics research, an enormous and remarkable mouse resource infrastructure has accumulated. This review summarizes those resources and provides practical guidelines for their use, particularly in the analysis of quantitative traits.
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