Characterization of an evolutionarily conserved far-upstream enhancer in the human α2 (I) collagen (COL1A2) gene
TT Antoniv, S De Val, D Wells, CP Denton… - Journal of Biological …, 2001 - jbc.org
We have examined the chromatin structure around and upstream of the transcriptional start
site of the human α2 (I) collagen (COL1A2) gene. Four strong DNase I-hypersensitive sites
(HS2–5) were only detected in fibroblasts, and a weaker one (HS1) was identified in type I
collagen-negative cells. Another hypersensitive site potentially involved in COL1A2
silencing was found in intron 1 (HS (In)). HS1 and HS2 were mapped within conserved
promoter sequences and at locations comparable to the mouse gene. HS3, HS4, and HS5 …
site of the human α2 (I) collagen (COL1A2) gene. Four strong DNase I-hypersensitive sites
(HS2–5) were only detected in fibroblasts, and a weaker one (HS1) was identified in type I
collagen-negative cells. Another hypersensitive site potentially involved in COL1A2
silencing was found in intron 1 (HS (In)). HS1 and HS2 were mapped within conserved
promoter sequences and at locations comparable to the mouse gene. HS3, HS4, and HS5 …
