[PDF][PDF] Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD
M van den Berge, CA Brandsma… - European …, 2019 - publications.ersnet.org
European Respiratory Journal, 2019•publications.ersnet.org
Several studies have shown that sexual dimorphisms exist with respect to the susceptibility
to smoking and the clinical presentation of COPD [1, 2]. Females with COPD have a faster
annual decline in their Forced Expiratory Volume in one second (FEV 1) than males, even
with a similar number of packyears smoking [3, 4]. In addition, females develop a different
type of COPD than males with less severe emphysematous destruction, but thicker small
airway walls [5]. Several factors may contribute to the observed sex differences, eg smoking …
to smoking and the clinical presentation of COPD [1, 2]. Females with COPD have a faster
annual decline in their Forced Expiratory Volume in one second (FEV 1) than males, even
with a similar number of packyears smoking [3, 4]. In addition, females develop a different
type of COPD than males with less severe emphysematous destruction, but thicker small
airway walls [5]. Several factors may contribute to the observed sex differences, eg smoking …
Several studies have shown that sexual dimorphisms exist with respect to the susceptibility to smoking and the clinical presentation of COPD [1, 2]. Females with COPD have a faster annual decline in their Forced Expiratory Volume in one second (FEV1) than males, even with a similar number of packyears smoking [3, 4]. In addition, females develop a different type of COPD than males with less severe emphysematous destruction, but thicker small airway walls [5]. Several factors may contribute to the observed sex differences, e.g. smoking behaviour or exposures to other environmental agents [6, 7].
European Respiratory Society