T cells and monocyte-derived myeloid cells mediate immunotherapy-related hepatitis in a mouse model
Background & Aims Immune checkpoint inhibitors (ICIs) are associated with immune-related
adverse events (irAEs) which are more severe when ICIs are used in combination. We
aimed to use a mouse model to elucidate the molecular mechanisms of immune-related
hepatitis, one of the common irAEs associated with ICIs. Methods Immune phenotyping and
molecular profiling were performed on Pdcd1-/-mice treated with anti-CTLA4 and/or the
IDO1 inhibitor epacadostat or a 4-1BB agonistic antibody. Results ICI combination-induced …
adverse events (irAEs) which are more severe when ICIs are used in combination. We
aimed to use a mouse model to elucidate the molecular mechanisms of immune-related
hepatitis, one of the common irAEs associated with ICIs. Methods Immune phenotyping and
molecular profiling were performed on Pdcd1-/-mice treated with anti-CTLA4 and/or the
IDO1 inhibitor epacadostat or a 4-1BB agonistic antibody. Results ICI combination-induced …
