[HTML][HTML] Transcriptional switch of hepatocytes initiates macrophage recruitment and T-cell suppression in endotoxemia
X Sun, J Wu, L Liu, Y Chen, Y Tang, S Liu, H Chen… - Journal of …, 2022 - Elsevier
Background & Aims The liver plays crucial roles in the regulation of immune defense during
acute systemic infections. However, the roles of liver cellular clusters and intercellular
communication in the progression of endotoxemia have not been well-characterized.
Methods Single-cell RNA sequencing analysis was performed, and the transcriptomes of
19,795 single liver cells from healthy and endotoxic mice were profiled. The spatial and
temporal changes in hepatocytes and non-parenchymal cell types were validated by …
acute systemic infections. However, the roles of liver cellular clusters and intercellular
communication in the progression of endotoxemia have not been well-characterized.
Methods Single-cell RNA sequencing analysis was performed, and the transcriptomes of
19,795 single liver cells from healthy and endotoxic mice were profiled. The spatial and
temporal changes in hepatocytes and non-parenchymal cell types were validated by …
