Type I interferons and dendritic cells in cancer immunotherapy
J Sprooten, P Agostinis, AD Garg - … Review of Cell and Molecular Biology, 2019 - Elsevier
Type I interferons (IFNs) facilitate cancer immunosurveillance, antitumor immunity and
antitumor efficacy of conventional cell death-inducing therapies (chemotherapy/radiotherapy
) as well as immunotherapy. Moreover, it is clear that dendritic cells (DCs) play a significant
role in aiding type I IFN-driven immunity. Owing to these antitumor properties several
immunotherapies involving, or inducing, type I IFNs have received considerable clinical
attention, eg, recombinant IFNα2 or agonists targeting pattern recognition receptor (PRR) …
antitumor efficacy of conventional cell death-inducing therapies (chemotherapy/radiotherapy
) as well as immunotherapy. Moreover, it is clear that dendritic cells (DCs) play a significant
role in aiding type I IFN-driven immunity. Owing to these antitumor properties several
immunotherapies involving, or inducing, type I IFNs have received considerable clinical
attention, eg, recombinant IFNα2 or agonists targeting pattern recognition receptor (PRR) …