Cell‐based therapies for wound repair are limited by inefficient delivery systems that fail to protect cells from the acute inflammatory environment. Here, a biomimetic hydrogel system is described that is based on the polymer pullulan, a carbohydrate glucan known to exhibit potent antioxidant capabilities. It is shown that pullulan hydrogels are an effective cell delivery system and improve mesenchymal stem cell survival and engraftment in high‐oxidative‐stress environments. The results suggest that glucan hydrogel systems may prove beneficial for progenitor‐cell‐based approaches to skin regeneration.