[HTML][HTML] IGFBP2 is a biomarker for predicting longitudinal deterioration in renal function in type 2 diabetes
RP Narayanan, B Fu, AH Heald… - Endocrine …, 2012 - ec.bioscientifica.com
RP Narayanan, B Fu, AH Heald, KW Siddals, RL Oliver, JE Hudson, A Payton, SG Anderson…
Endocrine connections, 2012•ec.bioscientifica.comObjective Insulin-like growth factors are implicated in the development of diabetic
nephropathy. IGF-binding protein 2 (IGFBP2) and IGF2 are expressed in the kidney, but their
associations with diabetic nephropathy are unclear. We therefore tested the hypothesis that
circulating levels of IGF2 and IGFBP2 predict longitudinal renal function in individuals with
type 2 diabetes.
nephropathy. IGF-binding protein 2 (IGFBP2) and IGF2 are expressed in the kidney, but their
associations with diabetic nephropathy are unclear. We therefore tested the hypothesis that
circulating levels of IGF2 and IGFBP2 predict longitudinal renal function in individuals with
type 2 diabetes.
Objective
Insulin-like growth factors are implicated in the development of diabetic nephropathy. IGF-binding protein 2 (IGFBP2) and IGF2 are expressed in the kidney, but their associations with diabetic nephropathy are unclear. We therefore tested the hypothesis that circulating levels of IGF2 and IGFBP2 predict longitudinal renal function in individuals with type 2 diabetes.
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