Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems☆
J Laurén, MS Airaksinen, M Saarma… - Molecular and Cellular …, 2003 - Elsevier
The regenerative capacity of the adult mammalian central nervous system is restricted by the
myelinating oligodendrocytes that form a nonpermissive environment for axonal growth.
Currently only the Nogo receptor (NgR), in complex with p75NTR neurotrophin receptor is
known to be involved in this inhibitory signalling in neurons. NgR is a common receptor for
the three inhibitory myelin proteins Nogo-A, OMgp, and MAG. Here we describe two novel
Nogo receptor gene homologs named NGRL2 and NGRL3 from human and mouse that, like …
myelinating oligodendrocytes that form a nonpermissive environment for axonal growth.
Currently only the Nogo receptor (NgR), in complex with p75NTR neurotrophin receptor is
known to be involved in this inhibitory signalling in neurons. NgR is a common receptor for
the three inhibitory myelin proteins Nogo-A, OMgp, and MAG. Here we describe two novel
Nogo receptor gene homologs named NGRL2 and NGRL3 from human and mouse that, like …