Macrophages are a heterogeneous cell type implicated in injury, repair, and fibrosis after
AKI, but the macrophage population associated with each phase is unclear. In this study, we
used a renal bilateral ischemia-reperfusion injury mouse model to identify unique monocyte/
macrophage populations by differential expression of Ly6C in CD11b+ cells and to define
the function of these cells in the pathophysiology of disease on the basis of microarray gene
signatures and reduction strategies. Macrophage populations were isolated from kidney …