[HTML][HTML] Cytomegalovirus infection of the central nervous system stem cells from mouse embryo: a model for developmental brain disorders induced by …
I Kosugi, Y Shinmura, H Kawasaki, Y Arai, RY Li… - Laboratory …, 2000 - Elsevier
Cytomegalovirus (CMV) is the most frequent infectious cause of developmental disorders of
the central nervous system (CNS) in humans. Infection of the CNS stem cells seems to be
primarily responsible for the generation of the brain abnormalities. In this study, we
evaluated the infectivity of murine CMV (MCMV) in epidermal growth factor (EGF)-
responsive CNS stem cells prepared from fetal mouse brains, and studied the effect of
infection on growth and differentiation of the stem cells. The CNS stem cells were permissive …
the central nervous system (CNS) in humans. Infection of the CNS stem cells seems to be
primarily responsible for the generation of the brain abnormalities. In this study, we
evaluated the infectivity of murine CMV (MCMV) in epidermal growth factor (EGF)-
responsive CNS stem cells prepared from fetal mouse brains, and studied the effect of
infection on growth and differentiation of the stem cells. The CNS stem cells were permissive …
