Commentary: HIV Vaccine Trial Exploits a Dual and Central Role for Innate Immunity
DH Fuller, LE Richert-Spuhler, NR Klatt - Journal of virology, 2014 - journals.asm.org
DH Fuller, LE Richert-Spuhler, NR Klatt
Journal of virology, 2014•journals.asm.orgLimited understanding of correlates of protection from HIV transmission hinders
development of an efficacious vaccine. DJM Lewis and colleagues (J. Virol. 88: 11648–
11657, 2014, doi: 10.1128/JVI. 01621-14) now report that vaginal immunization with an
HIVgp140 vaccine linked to the 70-kDa heat shock protein downregulated the human
immunodeficiency virus (HIV) coreceptor CCR5 (chemokine [CC motif] receptor 5) and
increased expression of the HIV resistance factor APOBEC3G (apolipoprotein B mRNA …
development of an efficacious vaccine. DJM Lewis and colleagues (J. Virol. 88: 11648–
11657, 2014, doi: 10.1128/JVI. 01621-14) now report that vaginal immunization with an
HIVgp140 vaccine linked to the 70-kDa heat shock protein downregulated the human
immunodeficiency virus (HIV) coreceptor CCR5 (chemokine [CC motif] receptor 5) and
increased expression of the HIV resistance factor APOBEC3G (apolipoprotein B mRNA …
Abstract
Limited understanding of correlates of protection from HIV transmission hinders development of an efficacious vaccine. D. J. M. Lewis and colleagues (J. Virol. 88:11648–11657, 2014, doi:10.1128/JVI.01621-14) now report that vaginal immunization with an HIVgp140 vaccine linked to the 70-kDa heat shock protein downregulated the human immunodeficiency virus (HIV) coreceptor CCR5 (chemokine [C-C motif] receptor 5) and increased expression of the HIV resistance factor APOBEC3G (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G), in women. These effects correlated with HIV suppression ex vivo. Thus, vaccine-induced innate responses not only facilitate adaptive immunity–they may prove to be critical for preventing HIV transmission.
American Society for Microbiology