A case for APRIL/BLyS directed therapy not eosinophil directed therapy for alloantibody elimination
RR Redfield, PL Abt, A Naji - American Journal of Transplantation, 2014 - amjtransplant.org
The recent article by Cravedi et al (1) indicates that eosinophils were not required for the
induction and maintenance of an alloantibody response. This is an important study which
highlights that strategies to deplete eosinophils are unlikely to result in a durable treatment
for sensitization to alloantibody, or elimination of an antibody response due to a redundancy
in cellular constituents who contribute to the survival of plasma cells in the bone marrow.
Numerous cell types including eosinophils, basophils and megakaryocytes contribute to …
induction and maintenance of an alloantibody response. This is an important study which
highlights that strategies to deplete eosinophils are unlikely to result in a durable treatment
for sensitization to alloantibody, or elimination of an antibody response due to a redundancy
in cellular constituents who contribute to the survival of plasma cells in the bone marrow.
Numerous cell types including eosinophils, basophils and megakaryocytes contribute to …