Enhanced innate type 2 immune response in peripheral blood from patients with asthma
KR Bartemes, GM Kephart, SJ Fox, H Kita - Journal of Allergy and Clinical …, 2014 - Elsevier
Background In mice, group 2 innate lymphoid cells (ILC2s) likely mediate helminth immunity,
inflammation, and tissue repair and remodeling. However, the involvement of ILC2s in
human diseases, such as asthma, is not well understood. Objectives The goals of this study
were to investigate whether peripheral blood specimens can be used to monitor innate type
2 immunity in human subjects and to examine whether ILC2s are involved in human asthma.
Methods PBMCs from subjects with allergic asthma (AA), subjects with allergic rhinitis (AR) …
inflammation, and tissue repair and remodeling. However, the involvement of ILC2s in
human diseases, such as asthma, is not well understood. Objectives The goals of this study
were to investigate whether peripheral blood specimens can be used to monitor innate type
2 immunity in human subjects and to examine whether ILC2s are involved in human asthma.
Methods PBMCs from subjects with allergic asthma (AA), subjects with allergic rhinitis (AR) …