Asthma: Mechanisms of Disease Persistence and Progression
L Cohn, JA Elias, GL Chupp - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract When asthma is diagnosed, eosinophilic inflammation and airway remodeling are
established in the bronchial airways and can no longer be separated as cause and effect
because both processes contribute to persistence and progression of disease, despite anti-
inflammatory therapy. Th2 cells are continually active in the airways, even when disease is
quiescent. IL-13 is the key effector cytokine in asthma and stimulates airway fibrosis through
the action of matrix metalloproteinases on TGF-β and promotes epithelial damage, mucus …
established in the bronchial airways and can no longer be separated as cause and effect
because both processes contribute to persistence and progression of disease, despite anti-
inflammatory therapy. Th2 cells are continually active in the airways, even when disease is
quiescent. IL-13 is the key effector cytokine in asthma and stimulates airway fibrosis through
the action of matrix metalloproteinases on TGF-β and promotes epithelial damage, mucus …
