[HTML][HTML] Evaluation of the DBA/2J mouse as a potential background strain for genetic models of cardiomyopathy
CC Hart, Y il Lee, DW Hammers… - Journal of molecular and …, 2022 - Elsevier
The potential use of the D2. mdx mouse (the mdx mutation on the DBA/2J genetic
background) as a preclinical model of the cardiac aspects of Duchenne muscular dystrophy
(DMD) has been criticized based on speculation that the DBA/2J genetic background
displays an inherent hypertrophic cardiomyopathy (HCM) phenotype. Accordingly, the goal
of the current study was to further examine the cardiac status of this mouse strain over a 12-
month period to determine if observable signs of HCM develop, including histopathology …
background) as a preclinical model of the cardiac aspects of Duchenne muscular dystrophy
(DMD) has been criticized based on speculation that the DBA/2J genetic background
displays an inherent hypertrophic cardiomyopathy (HCM) phenotype. Accordingly, the goal
of the current study was to further examine the cardiac status of this mouse strain over a 12-
month period to determine if observable signs of HCM develop, including histopathology …
