Expression of the folate receptor genes FOLR1 and FOLR3 differentiates ovarian carcinoma from breast carcinoma and malignant mesothelioma in serous effusions
Y Yuan, DA Nymoen, HP Dong, O Bjørang, IM Shih… - Human pathology, 2009 - Elsevier
The objective of this study was to analyze the diagnostic and clinical role of the folate
receptor-α (FOLR1) and folate receptor-γ (FOLR3) genes in effusion cytology. Expression of
the FOLR1 protein product, FR-α, was additionally studied. Ninety-one effusions (71 ovarian
carcinomas, 10 breast carcinomas, 10 malignant mesotheliomas) were assayed for FOLR1
and FOLR3 gene expression using quantitative polymerase chain reaction. FR-α expression
was analyzed using flow cytometry. Ovarian carcinoma expression levels were analyzed for …
receptor-α (FOLR1) and folate receptor-γ (FOLR3) genes in effusion cytology. Expression of
the FOLR1 protein product, FR-α, was additionally studied. Ninety-one effusions (71 ovarian
carcinomas, 10 breast carcinomas, 10 malignant mesotheliomas) were assayed for FOLR1
and FOLR3 gene expression using quantitative polymerase chain reaction. FR-α expression
was analyzed using flow cytometry. Ovarian carcinoma expression levels were analyzed for …
