Mechanisms of membrane transport of folates into cells and across epithelia
R Zhao, N Diop-Bove, M Visentin… - Annual review of …, 2011 - annualreviews.org
Until recently, the transport of folates into cells and across epithelia has been interpreted
primarily within the context of two transporters with high affinity and specificity for folates, the
reduced folate carrier and the folate receptors. However, there were discrepancies between
the properties of these transporters and characteristics of folate transport in many tissues,
most notably the intestinal absorption of folates, in terms of pH dependency and substrate
specificity. With the recent cloning of the proton-coupled folate transporter (PCFT) and the …
primarily within the context of two transporters with high affinity and specificity for folates, the
reduced folate carrier and the folate receptors. However, there were discrepancies between
the properties of these transporters and characteristics of folate transport in many tissues,
most notably the intestinal absorption of folates, in terms of pH dependency and substrate
specificity. With the recent cloning of the proton-coupled folate transporter (PCFT) and the …
