Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients
FC Barreto, DV Barreto, S Liabeuf… - Clinical Journal of the …, 2009 - journals.lww.com
Clinical Journal of the American Society of Nephrology, 2009•journals.lww.com
Background and objectives: As a major component of uremic syndrome, cardiovascular
disease is largely responsible for the high mortality observed in chronic kidney disease
(CKD). Preclinical studies have evidenced an association between serum levels of indoxyl
sulfate (IS, a protein-bound uremic toxin) and vascular alterations. The aim of this study is to
investigate the association between serum IS, vascular calcification, vascular stiffness, and
mortality in a cohort of CKD patients.
disease is largely responsible for the high mortality observed in chronic kidney disease
(CKD). Preclinical studies have evidenced an association between serum levels of indoxyl
sulfate (IS, a protein-bound uremic toxin) and vascular alterations. The aim of this study is to
investigate the association between serum IS, vascular calcification, vascular stiffness, and
mortality in a cohort of CKD patients.
Abstract
Background and objectives: As a major component of uremic syndrome, cardiovascular disease is largely responsible for the high mortality observed in chronic kidney disease (CKD). Preclinical studies have evidenced an association between serum levels of indoxyl sulfate (IS, a protein-bound uremic toxin) and vascular alterations. The aim of this study is to investigate the association between serum IS, vascular calcification, vascular stiffness, and mortality in a cohort of CKD patients.
Lippincott Williams & Wilkins