Aryl hydrocarbon receptor deficiency enhances insulin sensitivity and reduces PPAR-α pathway activity in mice
C Wang, CX Xu, SL Krager, KM Bottum… - Environmental …, 2011 - ehp.niehs.nih.gov
Background: Numerous man-made pollutants activate the aryl hydrocarbon receptor (AhR)
and are risk factors for type 2 diabetes. AhR signaling also affects molecular clock genes to
influence glucose metabolism. Objective: We investigated mechanisms by which AhR
activation affects glucose metabolism. Methods: Glucose tolerance, insulin resistance, and
expression of peroxisome proliferator–activated receptor-α (PPAR-α) and genes affecting
glucose metabolism or fatty acid oxidation and clock gene rhythms were investigated in wild …
and are risk factors for type 2 diabetes. AhR signaling also affects molecular clock genes to
influence glucose metabolism. Objective: We investigated mechanisms by which AhR
activation affects glucose metabolism. Methods: Glucose tolerance, insulin resistance, and
expression of peroxisome proliferator–activated receptor-α (PPAR-α) and genes affecting
glucose metabolism or fatty acid oxidation and clock gene rhythms were investigated in wild …