Accumulation of protein-bound uremic toxins: the kidney remains the leading culprit in the gut-liver-kidney axis
N Jourde-Chiche, S Burtey - Kidney International, 2020 - Elsevier
N Jourde-Chiche, S Burtey
Kidney International, 2020•ElsevierProtein-bound uremic toxins (PBUTs) accumulate in chronic kidney disease (CKD) and are
poorly removed by dialysis. Gryp et al. demonstrated that fecal bacteria from patients with
CKD do not produce more PBUTs than do those from healthy controls and that the
accumulation of PBUTs, as CKD progresses, is mainly due to their reduced renal elimination
by glomerular filtration and tubular secretion. This work underlines the importance of
studying the metabolism of PBUTs along the diet-gut-liver-kidney axis.
poorly removed by dialysis. Gryp et al. demonstrated that fecal bacteria from patients with
CKD do not produce more PBUTs than do those from healthy controls and that the
accumulation of PBUTs, as CKD progresses, is mainly due to their reduced renal elimination
by glomerular filtration and tubular secretion. This work underlines the importance of
studying the metabolism of PBUTs along the diet-gut-liver-kidney axis.
Protein-bound uremic toxins (PBUTs) accumulate in chronic kidney disease (CKD) and are poorly removed by dialysis. Gryp et al. demonstrated that fecal bacteria from patients with CKD do not produce more PBUTs than do those from healthy controls and that the accumulation of PBUTs, as CKD progresses, is mainly due to their reduced renal elimination by glomerular filtration and tubular secretion. This work underlines the importance of studying the metabolism of PBUTs along the diet-gut-liver-kidney axis.
Elsevier
