Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes
AC Figueiredo, C Wasmeier, AK Tarafder… - Journal of Biological …, 2008 - jbc.org
Rab GTPases regulate discrete steps in vesicular transport pathways. Rabs require
activation by specific guanine nucleotide exchange factors (GEFs) that stimulate the
exchange of GDP for GTP. Rab27a controls motility and regulated exocytosis of secretory
granules and related organelles. In melanocytes, Rab27a regulates peripheral transport of
mature melanosomes by recruiting melanophilin and myosin Va. Here, we studied the
activation of Rab27a in melanocytes. We identify Rab3GEP, previously isolated as a GEF for …
activation by specific guanine nucleotide exchange factors (GEFs) that stimulate the
exchange of GDP for GTP. Rab27a controls motility and regulated exocytosis of secretory
granules and related organelles. In melanocytes, Rab27a regulates peripheral transport of
mature melanosomes by recruiting melanophilin and myosin Va. Here, we studied the
activation of Rab27a in melanocytes. We identify Rab3GEP, previously isolated as a GEF for …
