TNF-α is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage
SA Vinores, WH Xiao, JK Shen… - Journal of …, 2007 - Elsevier
Vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α) show
significant overlap with regard to their effects in the eye. It has been postulated that VEGF-
induced leukostasis, breakdown of the blood–retinal barrier, and ischemia-induced retinal
neovascularization may be mediated, at least in part, through TNF-α. In this study, we used
mice deficient in TNF-α to test our hypothesis. Compared to wild type mice, TNF-α-deficient
mice showed an 80% reduction in leukocyte accumulation in retinal vessels after …
significant overlap with regard to their effects in the eye. It has been postulated that VEGF-
induced leukostasis, breakdown of the blood–retinal barrier, and ischemia-induced retinal
neovascularization may be mediated, at least in part, through TNF-α. In this study, we used
mice deficient in TNF-α to test our hypothesis. Compared to wild type mice, TNF-α-deficient
mice showed an 80% reduction in leukocyte accumulation in retinal vessels after …