Genomic structure of human FLT3: implications for mutational analysis.
FM Abu-Duhier, AC Goodeve… - British journal of …, 2001 - search.ebscohost.com
FM Abu-Duhier, AC Goodeve, GA Wilson, RS Care, IR Peake, JT Reilly
British journal of haematology, 2001•search.ebscohost.comCorrespondence Page 1 1076 q 2001 Blackwell Science Ltd Correspondence GENOMIC
STRUCTURE OF HUMAN FLT3: IMPLICATIONS FOR MUTATIONAL ANALYSIS The FLT3
gene encodes a class III receptor tyrosine kinase (RTKIII) that has the same overall structure as
c-kit, c-fms and the platelet-derived growth factor receptors a and b. The genomic loci encoding
RTKIII receptors share overall conservation of exon size, number, sequence and exon/ intron
boundary positions, suggesting that they have arisen from a common ancestral gene (AgneÁs …
STRUCTURE OF HUMAN FLT3: IMPLICATIONS FOR MUTATIONAL ANALYSIS The FLT3
gene encodes a class III receptor tyrosine kinase (RTKIII) that has the same overall structure as
c-kit, c-fms and the platelet-derived growth factor receptors a and b. The genomic loci encoding
RTKIII receptors share overall conservation of exon size, number, sequence and exon/ intron
boundary positions, suggesting that they have arisen from a common ancestral gene (AgneÁs …
Abstract
Presents a study on the implications of genomic sequences complimentary to human FLT3 messenger RNA for mutational analysis. Information on the FLT3 gene; Exons encoding the human FLT3; Key findings.
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