Cardiac wound healing post-myocardial infarction: a novel method to target extracellular matrix remodeling in the left ventricle
R Zamilpa, J Zhang, YA Chiao… - … and Repair: Methods …, 2013 - Springer
Wound Regeneration and Repair: Methods and Protocols, 2013•Springer
Myocardial infarction (MI) is a leading cause of death worldwide. Permanent ligation of the
left anterior descending coronary artery (LAD) is a commonly used surgical model to study
post-MI effects in mice. LAD occlusion induces a robust wound healing response that
includes extracellular matrix (ECM) remodeling. This chapter provides a detailed guide on
the surgical procedure to permanently ligate the LAD. Additionally, we describe a prototype
method to enrich cardiac tissue for ECM, which allows one to focus on ECM remodeling in …
left anterior descending coronary artery (LAD) is a commonly used surgical model to study
post-MI effects in mice. LAD occlusion induces a robust wound healing response that
includes extracellular matrix (ECM) remodeling. This chapter provides a detailed guide on
the surgical procedure to permanently ligate the LAD. Additionally, we describe a prototype
method to enrich cardiac tissue for ECM, which allows one to focus on ECM remodeling in …
Abstract
Myocardial infarction (MI) is a leading cause of death worldwide. Permanent ligation of the left anterior descending coronary artery (LAD) is a commonly used surgical model to study post-MI effects in mice. LAD occlusion induces a robust wound healing response that includes extracellular matrix (ECM) remodeling. This chapter provides a detailed guide on the surgical procedure to permanently ligate the LAD. Additionally, we describe a prototype method to enrich cardiac tissue for ECM, which allows one to focus on ECM remodeling in the left ventricle following surgically induced MI in mice.
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