Histopathologic and autofluorescence investigations were carried out to study lipofuscin
pigment accumulation in various age groups of human beings died in accidents (in 100
cases ranging from 1–70 years-of-age). Lipofuscin pigment granules were first observed to
appear at 9 years of age. Qualitative studies revealed a progressive increase in the
intracellular lipofuscin pigment accumulation with advancing age. These pigment granules
were found to congregate in mass in nerve cells of old individuals. An increase in the …