Immunogenicity of murine solid tumor models as a defining feature of in vivo behavior and response to immunotherapy
MG Lechner, SS Karimi, K Barry-Holson… - Journal of …, 2013 - journals.lww.com
Immune profiling has been widely used to probe mechanisms of immune escape in cancer
and identify novel targets for therapy. Two emerging uses of immune signatures are to
identify likely responders to immunotherapy regimens among individuals with cancer and to
understand the variable responses seen among subjects with cancer in immunotherapy
trials. Here, the immune profiles of 6 murine solid tumor models (CT26, 4T1, MAD109,
RENCA, LLC, and B16) were correlated to tumor regression and survival in response to 2 …
and identify novel targets for therapy. Two emerging uses of immune signatures are to
identify likely responders to immunotherapy regimens among individuals with cancer and to
understand the variable responses seen among subjects with cancer in immunotherapy
trials. Here, the immune profiles of 6 murine solid tumor models (CT26, 4T1, MAD109,
RENCA, LLC, and B16) were correlated to tumor regression and survival in response to 2 …