Current clinical trials testing combinations of immunotherapy and radiation

M Crittenden, H Kohrt, R Levy, J Jones… - Seminars in radiation …, 2015 - Elsevier
Preclinical evidence of successful combinations of ionizing radiation with immunotherapy
has inspired testing the translation of these results to the clinic. Interestingly, the preclinical
work has consistently predicted the responses encountered in clinical trials. The first
example came from a proof-of-principle trial started in 2001 that tested the concept that
growth factors acting on antigen-presenting cells improve presentation of tumor antigens
released by radiation and induce an abscopal effect. Granulocyte-macrophage colony …