Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival
CM Ohri, A Shikotra, RH Green… - European …, 2009 - Eur Respiratory Soc
CM Ohri, A Shikotra, RH Green, DA Waller, P Bradding
European Respiratory Journal, 2009•Eur Respiratory SocThere is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC)
expressing high numbers of macrophages in their tumour islets. The primary aim of the
present study was to determine the immunological phenotype of NSCLC-associated
macrophages. CD68+ macrophages expressing markers of a cytotoxic M1 phenotype or a
noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected
tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor …
expressing high numbers of macrophages in their tumour islets. The primary aim of the
present study was to determine the immunological phenotype of NSCLC-associated
macrophages. CD68+ macrophages expressing markers of a cytotoxic M1 phenotype or a
noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected
tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor …
There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. The primary aim of the present study was to determine the immunological phenotype of NSCLC-associated macrophages.
CD68+ macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry.
The islet density of both M1 and M2 macrophages was markedly increased in extended compared with poor survival patients. In the extended survival group, M1 islet density was significantly increased compared with M2 density, 70% of islet macrophages were positive for M1 markers versus 38% for M2, and the islet:stromal ratio of M1 macrophages was markedly increased compared with M2. The 5-yr survival for patients with above and below median expression of M1 macrophages in the islets was >75 and <5%, respectively.
Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. The survival advantage conferred by islet macrophage infiltration may be related to their cytotoxic antitumour activity.
European Respiratory Society