Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9
K Ly, YGL Saavedra, M Canuel, S Routhier… - Journal of Biological …, 2014 - ASBMB
Annexin A2 (AnxA2) was reported to be an extracellular endogenous inhibitor of proprotein
convertase subtilisin kexin type 9 (PCSK9) activity on cell-surface LDL receptor degradation.
In this study, we investigated the effect of silencing the expression of AnxA2 and PCSK9 in
HepG2 and Huh7 cells to better define the role of AnxA2 in PCSK9 regulation. AnxA2
knockdown in Huh7 cells significantly increased PCSK9 protein levels as opposed to AnxA2
knockdown in HepG2 cells. However, HepG2 cells overexpressing AnxA2 had lower levels …
convertase subtilisin kexin type 9 (PCSK9) activity on cell-surface LDL receptor degradation.
In this study, we investigated the effect of silencing the expression of AnxA2 and PCSK9 in
HepG2 and Huh7 cells to better define the role of AnxA2 in PCSK9 regulation. AnxA2
knockdown in Huh7 cells significantly increased PCSK9 protein levels as opposed to AnxA2
knockdown in HepG2 cells. However, HepG2 cells overexpressing AnxA2 had lower levels …
