Validation of coronary flow reserve measurements by thermodilution in clinical practice
E Barbato, W Aarnoudse… - European Heart …, 2004 - academic.oup.com
European Heart Journal, 2004•academic.oup.com
Background Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide
complementary information on the coronary circulation. Using a pressure wire, it is possible
to calculate CFR by thermodilution (CFR thermo), so that FFR and CFR can be measured
with a single guide wire. The present multicentric study was performed to compare the
feasibility of CFR thermo obtained with an improved algorithm and a standardized injection
technique and its agreement with Doppler-derived CFR (CFR Doppler). Methods and results …
complementary information on the coronary circulation. Using a pressure wire, it is possible
to calculate CFR by thermodilution (CFR thermo), so that FFR and CFR can be measured
with a single guide wire. The present multicentric study was performed to compare the
feasibility of CFR thermo obtained with an improved algorithm and a standardized injection
technique and its agreement with Doppler-derived CFR (CFR Doppler). Methods and results …
Abstract
Background Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFRthermoobtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFRDoppler).
Methods and results In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermoand CFRDopplerwere measured. FFR could be obtained in all patients (100%). An optimal CFRDopplercould be obtained in 69% of the patients. CFRthermocould be obtained in 97% of the patients. A significant correlation was found between CFRDopplerand CFRthermo(r=0.79, P<0.0001) but CFRthermotended to be higher than CFRDoppler.
Conclusions In a setting close to ‘real world’ practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.
Oxford University Press