Adipocyte purinergic receptors activated by uracil nucleotides as obesity and type 2 diabetes targets
S Jain, KA Jacobson - Current opinion in pharmacology, 2022 - Elsevier
Extracellular uridine nucleotides regulate physiological and pathophysiological metabolic
processes through the activation of P2Y 2, P2Y 4, P2Y 6 and P2Y 14 purinergic receptors,
which play a key role in adipogenesis, glucose uptake, lipolysis and adipokine secretion.
Using adipocyte-specific knockout mouse models, it has been demonstrated that lack of the
P2Y 6 R or P2Y 14 R can protect against diet-induced obesity and improve whole-body
glucose metabolism. The P2Y 2 R facilitated adipogenesis and inflammation, and the loss of …
processes through the activation of P2Y 2, P2Y 4, P2Y 6 and P2Y 14 purinergic receptors,
which play a key role in adipogenesis, glucose uptake, lipolysis and adipokine secretion.
Using adipocyte-specific knockout mouse models, it has been demonstrated that lack of the
P2Y 6 R or P2Y 14 R can protect against diet-induced obesity and improve whole-body
glucose metabolism. The P2Y 2 R facilitated adipogenesis and inflammation, and the loss of …