Nonopsonic Phagocytosis of Erythrocytes Infected with Ring-Stage Plasmodium falciparum
K Ayi, SN Patel, L Serghides, TG Smith… - Infection and …, 2005 - journals.asm.org
Ring-stage parasitized erythrocytes (RPEs) were demonstrated to interact with effector cells
of the innate immune system. With receptor blockade studies and CD36-null macrophages,
human and murine macrophages were shown to phagocytose RPEs through the pattern
recognition receptor CD36. These in vitro data implicate scavenger receptors in the
clearance of RPEs.
of the innate immune system. With receptor blockade studies and CD36-null macrophages,
human and murine macrophages were shown to phagocytose RPEs through the pattern
recognition receptor CD36. These in vitro data implicate scavenger receptors in the
clearance of RPEs.
Abstract
Ring-stage parasitized erythrocytes (RPEs) were demonstrated to interact with effector cells of the innate immune system. With receptor blockade studies and CD36-null macrophages, human and murine macrophages were shown to phagocytose RPEs through the pattern recognition receptor CD36. These in vitro data implicate scavenger receptors in the clearance of RPEs.
American Society for Microbiology