The IL-12p70/IL-10 interplay is differentially regulated by free heme and hemozoin in murine bone-marrow-derived macrophages
M Cambos, S Bazinet, E Abed… - International journal for …, 2010 - Elsevier
The outcome of malarial anemia is determined by a complex interplay between pro-
inflammatory and anti-inflammatory cytokines, its severity associated with accumulation of
hemozoin (Hz) in macrophages, elevated IL-10 responses and impaired IL-12 production.
Although free heme contributes to malarial anemia by inducing oxidative damage of red
blood cells (RBCs) and enhancing their clearance by phagocytes, its impact on IL-12/IL-10
interactions has not been fully characterized. Herein, the effect of hemin (HE) on IL-12 and IL …
inflammatory and anti-inflammatory cytokines, its severity associated with accumulation of
hemozoin (Hz) in macrophages, elevated IL-10 responses and impaired IL-12 production.
Although free heme contributes to malarial anemia by inducing oxidative damage of red
blood cells (RBCs) and enhancing their clearance by phagocytes, its impact on IL-12/IL-10
interactions has not been fully characterized. Herein, the effect of hemin (HE) on IL-12 and IL …