[HTML][HTML] Biology of IL-27 and its role in the host immunity against Mycobacterium tuberculosis
AE Abdalla, Q Li, L Xie, J Xie - International journal of biological …, 2015 - ncbi.nlm.nih.gov
AE Abdalla, Q Li, L Xie, J Xie
International journal of biological sciences, 2015•ncbi.nlm.nih.govIL-27, a heterodimeric cytokine of IL-12 family, regulates both innate and adaptive immunity
largely via Jak-Stat signaling. IL-27 can induce IFN-γ and inflammatory mediators from T
lymphocytes and innate immune cells. IL-27 has unique anti-inflammatory properties via
both Tr1 cells dependent and independent mechanisms. Here the role and biology of IL-27
in innate and adaptive immunity are summarized, with special interest with immunity against
Mycobacterium tuberculosis.
largely via Jak-Stat signaling. IL-27 can induce IFN-γ and inflammatory mediators from T
lymphocytes and innate immune cells. IL-27 has unique anti-inflammatory properties via
both Tr1 cells dependent and independent mechanisms. Here the role and biology of IL-27
in innate and adaptive immunity are summarized, with special interest with immunity against
Mycobacterium tuberculosis.
Abstract
IL-27, a heterodimeric cytokine of IL-12 family, regulates both innate and adaptive immunity largely via Jak-Stat signaling. IL-27 can induce IFN-γ and inflammatory mediators from T lymphocytes and innate immune cells. IL-27 has unique anti-inflammatory properties via both Tr1 cells dependent and independent mechanisms. Here the role and biology of IL-27 in innate and adaptive immunity are summarized, with special interest with immunity against Mycobacterium tuberculosis.
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