Association of transmission intensity and age with clinical manifestations and case fatality of severe Plasmodium falciparum malaria
H Reyburn, R Mbatia, C Drakeley, J Bruce, I Carneiro… - Jama, 2005 - jamanetwork.com
ContextThere are concerns that malaria control measures such as use of insecticide-treated
bed nets, by delaying acquisition of immunity, might result in an increase in the more severe
manifestations of malaria. An understanding of the relationships among the level of
exposure to Plasmodium falciparum, age, and severity of malaria can provide evidence of
whether this is likely. ObjectiveTo describe the clinical manifestations and case fatality of
severe P falciparum malaria at varying altitudes resulting in varying levels of transmission …
bed nets, by delaying acquisition of immunity, might result in an increase in the more severe
manifestations of malaria. An understanding of the relationships among the level of
exposure to Plasmodium falciparum, age, and severity of malaria can provide evidence of
whether this is likely. ObjectiveTo describe the clinical manifestations and case fatality of
severe P falciparum malaria at varying altitudes resulting in varying levels of transmission …