Polymorphisms of AIRE, a transcription factor that up-regulates intrathymic expression of
tissue-specific antigens including melanoma-associated antigens (MAAs), may variably
affect the selection of MAAs-specific thymocytes, generating T-cell repertoires protecting or
predisposing individuals to melanoma. We found that AIRE single nucleotide
polymorphisms (SNPs) rs1055311, rs1800520 and rs1800522 were significantly more
frequent in healthy subjects than in melanoma patients, independently from sex, age and …