[HTML][HTML] High affinity binding of β2-glycoprotein I to human endothelial cells is mediated by annexin II
K Ma, R Simantov, JC Zhang, R Silverstein… - Journal of Biological …, 2000 - ASBMB
β 2-Glycoprotein I (β 2 GPI) is an abundant plasma phospholipid-binding protein and an
autoantigen in the antiphospholipid antibody syndrome. Binding of β 2 GPI to endothelial
cells targets them for activation by anti-β 2 GPI antibodies, which circulate and are
associated with thrombosis in patients with the antiphospholipid antibody syndrome.
However, the binding of β 2 GPI to endothelial cells has not been characterized and is
assumed to result from association of β 2 GPI with membrane phospholipid. Here, we …
autoantigen in the antiphospholipid antibody syndrome. Binding of β 2 GPI to endothelial
cells targets them for activation by anti-β 2 GPI antibodies, which circulate and are
associated with thrombosis in patients with the antiphospholipid antibody syndrome.
However, the binding of β 2 GPI to endothelial cells has not been characterized and is
assumed to result from association of β 2 GPI with membrane phospholipid. Here, we …